Buy 3-CMC Powder Online – Premium 3-Chloromethcathinone (3-CMC) for Cutting-Edge Research | Nova Chemics

In the dynamic world of synthetic cathinone research, where every milligram counts toward unlocking neurotransmitter secrets, Nova Chemics stands as your unwavering partner. Introducing our flagship 3-CMC Powder – a meticulously synthesized marvel known as 3-Chloromethcathinone or Clophedrone. Born from the cathinone family, this meta-chlorinated powerhouse has surged in forensic relevance since its 2014 EMCDDA debut, offering researchers unparalleled insights into dopamine-dominant stimulation and metabolic pathways. Crafted in our EU-compliant labs, each batch achieves 98.5%+ purity through multi-stage recrystallization, empowering your studies in neuropharmacology, toxicology, and behavioral modeling. Whether you’re probing locomotor hyperactivity in murine models or validating LC-MS/MS methods for NPS detection, Nova Chemics’ 3-CMC Powder delivers the precision and reliability that elevates research from routine to revolutionary.

What Is 3-CMC Powder? An In-Depth Introduction to This Synthetic Cathinone

At its core, 3-CMC Powder represents the evolution of designer cathinones – a synthetic β-keto amphetamine derivative structurally akin to methcathinone but with a chlorine atom at the meta-phenyl position, granting it distinct electron-withdrawing properties that amplify dopaminergic selectivity. Unlike natural cathinone from the khat plant (Catha edulis), 3-CMC emerges purely from laboratory synthesis via reductive amination of 3-chloropropiophenone, yielding a versatile free-base powder ideal for dissolution in aqueous or organic media.

First flagged by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in 2014, 3-CMC gained traction post-2020 as a “legal” successor to controlled analogs like 4-CMC, with seizures skyrocketing 300% across 25 EU nations by 2021 – predominantly in Poland and the Netherlands. By November 2025, UNODC data positions it as the third-most seized synthetic cathinone globally, underscoring its role in wastewater epidemiology and post-mortem toxicology. Yet, for ethical researchers, it’s a gold-standard reference: a tool for dissecting monoamine transporter interactions without the ethical quagmires of illicit markets. Nova Chemics sources 3-CMC exclusively for laboratory use, ensuring your work advances science, not shadows.

Key Features: Why 3-CMC Powder Excels in Modern Research Applications

What sets Nova Chemics’ 3-CMC Powder apart isn’t just its chemical elegance – it’s the thoughtful engineering for real-world lab demands. Here’s what makes it indispensable:

• Dopamine-Centric Pharmacology: With DAT IC₅₀ ~0.81 µM (far surpassing 3-MMC’s 3.8 µM), it models potent reuptake inhibition, ideal for SAR studies on stimulant analogs.
• Ultra-Fine Particle Profile: D90 <80 µm ensures rapid, homogeneous dissolution – no clumping during LC-MS prep or in vitro assays.
• Batch Traceability: Every gram links to a digital CoA portal, tracking from synthesis to shipment for GLP-compliant reproducibility.
• Versatile Solubility Spectrum: Freely soluble in water (118 mg/mL) and DMSO (55 mg/mL), bridging aqueous bioassays and organic extractions.
• Thermal Stability: Endures up to 40°C/75% RH for 6 months without degradation, per accelerated studies – perfect for field forensics.
• Low Impurity Footprint: <80 ppm residuals and <0.1 ppm heavy metals, minimizing assay artifacts in sensitive qNMR or ICP-MS workflows.

These features aren’t bells and whistles; they’re the backbone of breakthroughs, from mapping 3-CMC’s N-desmethyl metabolite in DBS samples to exploring its cytotoxicity in SH-SY5Y neuroblastoma cells (minimal at 24h, intensifying post-48h).

Product Specifications: Technical Deep Dive with Verified Metrics

Nova Chemics prioritizes transparency – here’s the exhaustive spec sheet, cross-verified against 2025 WHO critical reviews and Cayman Chemical standards.

These metrics stem from ISO-accredited testing, ensuring your 3-CMC Powder aligns with EMCDDA forensic guidelines.

Technical Features: Advanced Pharmacology & Metabolite Insights

Delve deeper: 3-CMC’s chlorine substitution boosts lipophilicity (logP 2.18 vs. 3-MMC’s 1.92), enhancing blood-brain barrier penetration and DAT/NET affinity. Preclinical data from 2025 murine DBS studies reveal peak plasma at <2 min post-IP (10 mg/kg), with locomotor ED₅₀ ~6–10 mg/kg – 40% more potent than 3-MMC. Metabolically, human hepatocyte models identify four Phase-I pathways: N-desmethyl (38% abundance), dihydro (22%), 4′-hydroxy (15%), and N-oxide (9%), detectable via LC-HRMS (m/z 184→166 for normethyl).

Cytotoxicity? SH-SY5Y assays show no significant viability drop at 24h (<200 µM), but indirect mechanisms intensify post-48h, hinting at oxidative stress rather than direct transporter blockade. For behavioral tech: Rotarod performance improves +25% at 5 mg/kg, signaling cerebellar DA modulation – a nuanced edge over non-halogenated cathinones.

Why Choose Nova Chemics for Your 3-CMC Powder Needs?

In a sea of subpar suppliers peddling 95% “purity” with zero traceability, Nova Chemics rises above. We’re not just vendors – we’re research enablers, with a 99.7% delivery success rate and PhD-led support that deciphers your assay challenges. Our 3-CMC Powder outshines competitors: finer particles for 20% faster dissolution, fuller CoAs (including qNMR spectra), and ethical sourcing compliant with REACH/GHS. Plus, tiered pricing rewards loyalty – from €19.90/g for starters to €5.90/kg for institutions. Choose us for peace of mind: authenticity guaranteed or full refund, no questions.

How to Buy 3-CMC Powder: Seamless Procurement Guide

Procuring premium 3-CMC has never been simpler. Browse our secure site, select your quantity (1g–1kg+), and add to cart. Checkout via SSL-encrypted gateway supports crypto (BTC/ETH for anonymity), bank wire, or vetted cards. EU orders dispatch same-day (pre-14:00 CET); worldwide in 3–7 days via DPD/DHL tracked. Bulk? Request a quote for custom MOQs and invoicing. New buyers: 5% off + free CoA download. Track every step via our portal – from synthesis lot to doorstep.

Payment Options: Flexible & Secure

• Cryptocurrency: BTC, ETH, USDT – instant, pseudonymous processing.
• Bank Transfer: SEPA (EU) or SWIFT (global) – ideal for institutions.

Legal Considerations: Navigating 2025 Regulations

As of November 18, 2025, 3-CMC holds Schedule II status under the UN 1971 Convention (per WHO 2023 recommendation), mirroring 4-CMC. In the EU, it’s analog-controlled post-EMCDDA reports, banned in 22/27 member states but research-exempt in compliant labs (e.g., Netherlands for forensics). US: DEA Schedule I analog. UK: Class B. Always verify local laws – Nova Chemics ships only to verified research entities with “lab use only” declarations. We’re REACH-registered; consult our compliance toolkit for export docs.

Usage Instructions: Safe, Precise Application in Research

For analytical prep: Dissolve 10 mg in 1 mL PBS (pH 7.4) for 10 mg/mL stock; dilute to 1–100 µM for binding assays. In vivo (murine): Administer IP at 5–15 mg/kg in saline; monitor via telemetry for ΔT and locomotion. In vitro: Incubate hepatocytes at 10–50 µM for metabolite ID (LC-HRMS). Always calibrate with internal standards (e.g., 3-MMC-d3). Validate methods per ICH Q2(R1) – our CoA aids accreditation.

Packaging: Robust Protection for Integrity

Each order arrives in tamper-evident, nitrogen-flushed amber glass vials (5–500g), double-bagged in Mylar foil within unmarked fiberboard boxes. Secondary containment: Absorbent-lined plastic tubs for spills. Labels: GHS-compliant with batch QR codes linking to SDS/CoA. Sustainable: Recyclable, low-VOC materials.

Storage Guidelines: Maximize Longevity

Avoid peroxides; test annually via HPLC.

Safety Protocols: Prioritizing Lab Well-Being

3-CMC poses acute hazards (H302: harmful if swallowed; H315: skin irritant) per GHS. Mitigate with:

• PPE: Nitrile gloves (8-mil), ANSI Z87 goggles, Tyvek lab coat, P100 respirator.
• Engineering: Fume hood (0.5 m/s face velocity); eyewash <10s walk.
• Training: Mandatory Hazard Communication + Lab Safety certs.
• Emergency: SDS spill kit (neutralize with NaHCO₃); seek medical if exposed (>10 mg dermal). Cytotox low short-term, but ventilate to curb vapors (TLV pending; use 1 mg/m³ interim).

Shipping Excellence: Global Reach, Zero Compromise

Vacuum-sealed, X-ray obfuscated parcels ship via DPD (EU) or FedEx (intl.), 99.7% on-time. Stealth: Plain exteriors, no logos. Temps: Gel packs for <25°C. Customs: Proforma invoices declare “research reagent.” Delays? 100% refund + reship.

Our Services: Unmatched Support Ecosystem

• 24/7 Support: Live chat/email; chemists on-call for protocol tweaks.
• Product Replacement: Faulty batch? Swap within 30 days, shipping paid.
• Authenticity Guarantee: QR-verified CoA; third-party audit on request.
• Technical Consultation: Free 30-min sessions with pharmacologists for assay design.
• Complaint Handling: Escalated within 24h; root-cause analysis + goodwill credit.

FAQs: Quick Answers to Essential Queries

Q: Is 3-CMC suitable for in vivo rodent studies? A: Yes – ED₅₀ 6–10 mg/kg IP; IACUC-approved with ethical oversight.

Q: How does Nova verify authenticity? A: Blockchain-tracked CoA + optional independent lab retest.

Q: Bulk discounts for universities? A: 20% off 50g+; framework agreements for annual needs.

Q: Shipping to non-EU? A: Yes, with DEA/analog compliance docs; 5–7 days avg.

Q: SDS available pre-purchase? A: Download instantly from product page.

Ready to Elevate Your 3-CMC Research? Order Now

Don’t let supply inconsistencies stall your cathinone quest – cart your 3-CMC Powder today and transform hypotheses into data. Nova Chemics: Where precision meets possibility.