Buy A-PiHP Crystal Online – Premium α-PiHP (Alpha-PiHP) for Research | Nova Chemics

When precision matters most, researchers worldwide turn to Nova Chemics for the highest-quality A-PiHP crystal available. Also known as α-Pyrrolidinoisohexanophenone or alpha-PiHP, this potent synthetic cathinone is manufactured under pharmaceutical-grade conditions to guarantee exceptional purity and batch-to-batch consistency. Every order includes a full certificate of analysis confirming purity above 98% through HPLC and GC-MS verification. As a leading supplier of research chemicals, Nova Chemics ensures our A-PiHP crystal meets the demands of cutting-edge studies in neuropharmacology, toxicology, and forensic science. With its emergence as a key compound in the cathinone family since 2016, alpha-PiHP has become essential for investigating novel psychoactive substances (NPS) and their impacts on monoamine systems.

What Is A-PiHP Crystal? Chemical Profile and Properties

A-PiHP (α-Pyrrolidinoisohexanophenone, CAS 2181620-71-1) belongs to the pyrrolidinophenone class of new psychoactive substances. With the molecular formula C₁₆H₂₃NO and molar mass of 245.366 g/mol, it features a distinctive isohexanophenone backbone substituted with a pyrrolidine ring. This structural modification gives Alpha-PiHP crystal its characteristic high dopamine transporter selectivity compared to earlier cathinones like α-PVP. First reported in forensic contexts in late 2015, alpha-PiHP emerged as a positional isomer of pyrovalerone derivatives, designed to explore quantitative structure-activity relationships (QSAR) in NDRI (norepinephrine-dopamine reuptake inhibitor) mechanisms. Its SMILES notation—CC(C)CC(C(=O)C1=CC=CC=C1)N2CCCC2—facilitates computational modeling, making it invaluable for in silico SAR studies.

In recent pharmacological research, Alpha-PiHP demonstrates potent inhibition of dopamine (DAT) and norepinephrine (NET) transporters, with binding affinities comparable to α-PVP but slightly lower potency in locomotor stimulation (ED50: 4.0 mg/kg in mice vs. 1.1 mg/kg for α-PVP). Stability studies indicate up to 2 years shelf life under proper conditions, with no significant degradation observed in controlled environments. For researchers seeking reliable alpha-PiHP crystal chunks or powder, Nova Chemics provides lab-verified material free from impurities like heavy metals or residual solvents.

Why Researchers Choose Nova Chemics A-PiHP Crystal

Scientists searching to buy A-PiHP online consistently select Nova Chemics because we deliver:

• Verified purity ≥98.5% (third-party tested via NMR, FTIR, and mass spectrometry)
• Large, clear crystal chunks or fine crystalline powder for precise dosing
• Complete analytical documentation with every shipment, including batch-specific CoA
• Competitive pricing on both small and bulk A-PiHP orders, with tiered discounts for institutional buyers
• Fast, discreet EU-to-worldwide shipping, compliant with international NPS regulations

Unlike generic suppliers, our alpha-PiHP undergoes rigorous QSAR validation to ensure reproducibility in experiments. Recent WHO critical reviews highlight A-PiHP’s role in NPS trend monitoring, with detections in post-mortem cases underscoring its forensic relevance—Nova Chemics equips labs with the tools to advance these insights safely.

A-PiHP Crystal for Forensic and Analytical Research

Forensic laboratories and toxicology centers rely on our A-PiHP crystal as a certified reference material for:

• Method development and validation (LC-MS/MS, GC-MS) in complex biological matrices
• Identification of designer cathinones in seized samples, aligning with EMCDDA guidelines
• Calibration of screening panels for emerging NPS, including positivity rate tracking (e.g., <1% in U.S. trend reports)
• Comparative metabolite profiling, with key α-PiHP metabolites including β-keto reduction, hydroxylation, and glucuronidation products

In a 2022 Finnish study, α-PiHP appeared in seven post-mortem cases, often co-detected with other substances—our high-purity crystals support accurate quantitation (LOD <0.1 ng/mL in LC-MS/MS). Bulk buyers appreciate our scalability for high-volume forensic workflows.

A-PiHP in Neuropharmacology and Receptor Binding Studies

Neuroscientists use high-purity A-PiHP crystal to investigate:

• Dopamine and norepinephrine reuptake inhibition (Ki values: DAT ~10-50 nM, NET ~100-500 nM)
• Structure-activity relationships within the cathinone family, including positional isomer comparisons (α-PiHP vs. α-PHP)
• Behavioral modeling of stimulant compounds in rodent models, revealing hyperlocomotion and hyperthermia
• Potential development of therapeutic NDRI analogs for ADHD or narcolepsy research

Preclinical data from 2025 mouse studies show α-PiHP induces significant body temperature elevation (ΔT >2°C at 5 mg/kg) and locomotor activity, with brain Cmax ~40% lower than α-PVP, explaining nuanced potency differences. Nova Chemics’ A-PiHP enables precise in vitro receptor binding assays, fostering breakthroughs in addiction pathway elucidation.

Quality Assurance – Why Our A-PiHP Crystal Is Laboratory Trusted

Every batch undergoes independent third-party analysis. We provide comprehensive reports including NMR spectra (distinct pyrrolidine peaks at 1.7-2.0 ppm), FTIR (C=O stretch ~1700 cm⁻¹), HPLC purity (>98%), and residual solvent testing (<500 ppm). When you order A-PiHP crystal from Nova Chemics, you receive material that meets the strictest academic and institutional standards, surpassing many competitors’ 95-97% benchmarks. Our EU facility adheres to REACH and GHS classifications, ensuring traceability from synthesis to shipment.

Safe & Discreet Worldwide Shipping for A-PiHP Crystal

We ship all orders in unmarked, secure packaging with full tracking. Most customers receive their A-PiHP crystal within 3–7 business days (subject to local import regulations). Secure SSL checkout and multiple payment methods—crypto, bank transfer, credit—ensure complete confidentiality. For international compliance, we include export docs noting research-only use; note that α-PiHP is controlled under analog laws in regions like the EU (post-2024 bans) and U.S. (Schedule I potential).

Proper Storage and Handling of A-PiHP Crystal

Store A-PiHP crystal in a cool, dry place below 25°C (ideally -20°C for long-term), protected from light and moisture to prevent hydrolysis. Use airtight containers with desiccant for optimal stability—shelf life exceeds 2 years under these conditions. Always handle under fume hood conditions with appropriate PPE (gloves, goggles, lab coat) to mitigate respiratory or dermal irritation risks. Full safety data sheets (SDS) accompany every shipment, detailing GHS hazards (H302: harmful if swallowed) and emergency protocols. For dissolution in assays, prioritize anhydrous solvents to maintain integrity.

Bulk A-PiHP Crystal Orders and Wholesale Pricing

Research institutions and analytical laboratories ordering larger quantities benefit from tiered wholesale pricing and dedicated account management. Contact our sales team for custom quotes on 10 g, 50 g, 100 g, or kilogram-scale A-PiHP crystal purchases. Volume discounts start at 15% for 50g+, with flexible MOQs for startups. Our scalable supply chain ensures consistent quality, even for high-demand forensic networks.

*Prices exclude shipping; loyalty discounts apply for repeat buyers. All tiers ≥98% purity.

Frequently Asked Questions About Buying A-PiHP Crystal

Is A-PiHP legal to purchase for research? Yes—strictly for laboratory and forensic research purposes (not for human consumption). Verify local regulations, as it’s controlled in many jurisdictions.

What payment methods do you accept? Crypto (BTC/ETH), bank transfer, and select traditional methods for secure transactions.

How quickly can I receive my A-PiHP crystal order? EU orders: 1–3 days | Worldwide: 3–7 days (tracked, discreet).

Do you offer A-PiHP powder instead of crystals? Yes—both forms available with identical purity and specs; specify at checkout.

What sets Nova Chemics apart from other A-PiHP suppliers? Our third-party verified >98% purity, detailed CoA, and research-focused support exceed competitors like BolChemist or CityChems, where purity often caps at 97%.

Ready to Order A-PiHP Crystal Today?

Add your desired quantity to cart and complete our secure checkout in under a minute. First-time buyers receive an automatic welcome discount, while returning customers enjoy loyalty pricing and priority shipping. Explore related cathinones like α-PHP for comparative studies—Nova Chemics stocks the full pyrrolidinophenone lineup.

Nova Chemics – Europe’s most trusted supplier of research-grade A-PiHP crystal and advanced cathinones. Order now and elevate your research with laboratory-verified quality you can depend on.